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Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life. Two segments of DNA can have shared ancestry because of three phenomena: either a speciation event (orthologs), or a duplication event (paralogs), or else a horizontal (or lateral) gene ...
In biology, homology is similarity in anatomical structures or genes between organisms of different taxa due to shared ancestry, regardless of current functional differences. Evolutionary biology explains homologous structures as retained heredity from a common ancestor after having been subjected to adaptive modifications for different ...
The difference between enzymatically active and inactive homologues has been noted (and in some cases, understood when comparing catalytically active and inactive proteins residing in recognisable families) for some time at the sequence level, [8] owing to the absence of key catalytic residues.
Knowing the sequence of the protein encoded by a gene can allow researchers to apply methods that find similarities among protein sequences that provide more information than similarities or differences among DNA sequences. If the genes of a gene family encode proteins, the term protein family is often used in an analogous manner to gene family.
Neofunctionalization is the process by which a gene acquires a new function after a gene duplication event. The figure shows that once a gene duplication event has occurred one gene copy retains the original ancestral function (represented by the green paralog), while the other acquires mutations that allow it to diverge and develop a new function (represented by the blue paralog).
Homology (anthropology), analogy between human beliefs, practices or artifacts owing to genetic or historical connections Homology (psychology), behavioral characteristics that have common origins in either evolution or development
Synteny (in the modern sense) between human and mouse chromosomes. Colors in the human chromosomes indicate regions homologous with parts of the mouse chromosome of the same color. For instance, sequences homologous to mouse chromosome 1 are primarily on human chromosomes 1 and 2, but also 6, 8, and 18.
Protein A, B and C are isoforms encoded from the same gene through alternative splicing.. A protein isoform, or "protein variant", [1] is a member of a set of highly similar proteins that originate from a single gene and are the result of genetic differences. [2]