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Due to these side effects and its red color, doxorubicin has earned the nickname "red devil" [24] [25] or "red death." [26] Chemotherapy can cause reactivation of hepatitis B, and doxorubicin-containing regimens are no exception. [27] [28] Doxorubicin and several chemotherapeutic drugs (including cyclophosphamide) can cause a loss of skin ...
Doxorubicin localisation to nuclei. Localisation of doxorubicin (red) in the nuclei of MCF-7 cc10 cells. Green fluorescence represents lysosome. [25] The anthracyclines have been widely studied for their interactions with cellular components and impact on cellular processes. This includes studies in cultured cells and in whole animal systems.
The CytRx oncology pipeline includes clinical trials involving their lead drug aldoxorubicin. Aldoxorubicin (formerly INNO-206) is a modified form of doxorubicin, the popular anthracycline chemotherapeutic agent known as "red death". Anthracyclines are a class of drugs that are among the most commonly used agents in the treatment of cancer.
GVD is a chemotherapy regimen, used for salvage treatment of relapsed or refractory Hodgkin disease, including those patients who relapse after stem cell transplantation. [1]
Red Death, a fictional disease in Osmosis Jones; Red Death, a fictional dragon in the 2010 film How to Train Your Dragon; Masque of the Red Death (Ravenloft), a campaign setting for the Dungeons & Dragons role-playing game; The Red Death, a New York death metal band "Red Death at 6:14", a single by the American garage rock band The White Stripes.
Infusion of R,C,H and O components of R-CHOP. Red flask contains doxorubicin (H), the most toxic component. Prednisolone (P) is administered on the next four or five days intravenously or in tablets. [1] CHOP is the acronym for a chemotherapy regimen used in the treatment of non-Hodgkin lymphoma. CHOP consists of:
cBR96-doxorubicin immunoconjugate (BMS-182248/SGN-15; also known as cBR96-Dox) is an antibody-drug conjugate or (ADC) directed to the Lewis-Y antigen designed for the treatment of cancer. The payload is the chemotherapy drug doxorubicin which is connected with a hydrazone linker to cysteine residues of the Lewis-Y specific (chimeric) monoclonal ...
The specific targeting of the doxorubicin to LHRH receptor bearing cells is also proposed to reduce the cardiotoxicity observed in the administration of unconjugated doxorubicin. Zoptarelin doxorubicin was invented by Andrew V. Schally while at the Tulane University School of Medicine , New Orleans and subsequently at the Sylvester ...