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  2. Methicillin-resistant Staphylococcus aureus - Wikipedia

    en.wikipedia.org/wiki/Methicillin-resistant...

    The mecA gene, which confers resistance to a number of antibiotics, is always present in MRSA and usually absent in MSSA; however, in some instances, the mecA gene is present in MSSA but is not expressed. Polymerase chain reaction (PCR) testing is the most precise method for identifying MRSA strains. Specialized culture media have been ...

  3. SCCmec - Wikipedia

    en.wikipedia.org/wiki/SCCmec

    SCCmec, or staphylococcal cassette chromosome mec, is a mobile genetic element of Staphylococcus bacterial species. This genetic sequence includes the mecA gene coding for resistance to the antibiotic methicillin and is the only known way for Staphylococcus strains to spread the gene in the wild by horizontal gene transfer. [1]

  4. Antibiotic sensitivity testing - Wikipedia

    en.wikipedia.org/wiki/Antibiotic_sensitivity_testing

    [9] [23] An example is the use of PCR to detect the mecA gene for beta-lactam resistant Staphylococcus aureus. [9] Other examples include assays for testing vancomycin resistance genes vanA and vanB in Enterococcus species, and antibiotic resistance in Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli. [9]

  5. Gene therapy - Wikipedia

    en.wikipedia.org/wiki/Gene_therapy

    Writing in 2018, in the Journal of Law and the Biosciences, Sherkow et al. argued for a narrower definition of gene therapy than the FDA's in light of new technology that would consist of any treatment that intentionally and permanently modified a cell's genome, with the definition of genome including episomes outside the nucleus but excluding ...

  6. FDA approves Pfizer's first gene therapy for rare inherited ...

    www.aol.com/news/fda-approves-pfizer-first-gene...

    The gene therapy will compete with Australia-based CSL Behring’s Hemgenix, a similar treatment that won FDA approval for hemophilia B in 2022. That drug has a similar list price of $3.5 million ...

  7. MECA - Wikipedia

    en.wikipedia.org/wiki/MECA

    Meca or MECA may refer to: Biology. mecA, responsible for methicillin resistance in MRSA; Meca, a snout moth genus in the subfamily Pyralinae; Places Meca ...

  8. Methicillin - Wikipedia

    en.wikipedia.org/wiki/Methicillin

    Resistance to methicillin is conferred by activation of a new bacterial penicillin binding protein (PBP) mecA gene. This encodes protein PBP2a. This encodes protein PBP2a. PBP2a works in a similar manner to other PBPs, but it binds β-lactams with very low affinity, meaning they do not compete efficiently with the natural substrate of the ...

  9. HEK 293 cells - Wikipedia

    en.wikipedia.org/wiki/HEK_293_cells

    They have been used as hosts for gene expression. Typically, these experiments involve transfecting in a gene (or combination of genes) of interest, and then analyzing the expressed protein . The widespread use of this cell line is due to its transfectability by the various techniques, including calcium phosphate method, achieving efficiencies ...