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Furthermore, after absorption from the gastrointestinal tract, such drugs must pass to the liver, where they may be extensively altered; this is known as the first pass effect of drug metabolism. Due to the digestive activity of the stomach and intestines, the oral route is unsuitable for certain substances, such as salvinorin A .
Sublingual administration is when medication is placed under the tongue to be absorbed by the body. The word "sublingual" means "under the tongue." Buccal administration involves placement of the drug between the gums and the cheek. These medications can come in the form of tablets, films, or sprays.
The sublingual gland (glandula sublingualis) is a seromucous polystomatic exocrine gland.Located underneath the oral diaphragm (diaphragma oris), the sublingual gland is the smallest and most diffuse of the three major salivary glands of the oral cavity, with the other two being the submandibular and parotid.
The parietal cells in the fundus of the stomach, produce a glycoprotein called intrinsic factor which is essential for the absorption of vitamin B12. Vitamin B12 (cobalamin), is carried to, and through the stomach, bound to a glycoprotein secreted by the salivary glands – transcobalamin I also called haptocorrin, which protects the acid ...
The thin strip of tissue that runs vertically from the floor of the mouth to the undersurface of the tongue is called the lingual frenulum. It tends to limit the movement of the tongue, and in some people, it is so short that it actually interferes with speaking. A hump of tissue near the base of the tongue houses a series of saliva gland ducts.
The floor is formed by the mylohyoid muscles and is occupied mainly by the anterior two-thirds of the tongue. A mucous membrane – the oral mucosa, lines the sides and under surface of the tongue to the gums, and lines the inner aspect of the jaw . It receives secretions from the submandibular and sublingual salivary glands.
The cells here may possess microvilli for maximizing the surface area for absorption, and these microvilli may form a brush border. Other cells may be ciliated to move mucus in the function of mucociliary clearance. Other ciliated cells are found in the fallopian tubes, the uterus and central canal of the spinal cord.
Further, because the secretory cells are of both serous and mucous types, the submandibular gland is a mixed gland, and though most of the cells are serous, the exudate is chiefly mucous. It has long striated ducts and short intercalated ducts. [7] The secretory acinar cells of the submandibular gland have distinct functions.