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Glibenclamide, also known as glyburide, is an antidiabetic medication used to treat type 2 diabetes. [1] It is recommended that it be taken together with diet and exercise. [1] It may be used with other antidiabetic medication. [1] It is not recommended for use by itself in type 1 diabetes. [1] It is taken by mouth. [1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ...
Alpha-glucosidase inhibitors are used to establish greater glycemic control over hyperglycemia in diabetes mellitus type 2, particularly with regard to postprandial hyperglycemia. The intake of a single dose before a meal containing complex carbohydrates clearly suppresses the glucose spike and may decrease the postprandial hyperglycemia ...
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The normal human body temperature can be as high as 37.7 °C (99.9 °F) in the late afternoon. [2] Hyperthermia requires an elevation from the temperature that would otherwise be expected. Such elevations range from mild to extreme; body temperatures above 40 °C (104 °F) can be life-threatening.
A 2022 study on the effect of heat on young people found that the critical wet-bulb temperature at which heat stress can no longer be compensated, T wb,crit, in young, healthy adults performing tasks at modest metabolic rates mimicking basic activities of daily life was much lower than the 35 °C (95 °F) usually assumed, at about 30.55 °C (86 ...
In human, the mean steady state clearance (CL ss /F) was 1.13 L/h across in 1 to 4 mg dose range. In the dose range, the mean half-life was 10.3 h. [2] Urine excretion was negligible amount in elimination of lobeglitazone in rat and human. [1] [2] The plasma protein binding of the drug is over 99%.