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Cerebral amyloid angiopathy (CAA) is a form of angiopathy in which amyloid beta peptide deposits in the walls of small to medium blood vessels of the central nervous system and meninges. [ 2 ] [ 3 ] The term congophilic is sometimes used because the presence of the abnormal aggregations of amyloid can be demonstrated by microscopic examination ...
However, several aspects of amyloid biology are still under investigation. For example, recent evidence has suggested that amyloid plaque formation is linked to brain microvascular trauma. [49] [50] Other research implicates chronic inflammation of the brain and immune dysfunction of the nervous system. [51] [52]
AL amyloidosis is caused by the deposition of abnormal antibody free light chains. The abnormal light chains are produced by monoclonal plasma cells, and, although AL amyloidosis can occur without diagnosis of another disorder, it is often associated with other plasma cell disorders, such as multiple myeloma and Waldenström's macroglobulinemia. [6]
The Boston criteria version 2.0 [1] is a set of guidelines designed to diagnose cerebral amyloid angiopathy (CAA), a disease that affects small blood vessels in the brain, particularly those in the cortex and leptomeninges. Although the gold standard for diagnosis is histopathological examination, the Boston criteria provide clinicians with a ...
Deposits of amyloid can begin accumulating in the brain decades before symptoms begin, even in a person’s 30s and 40s. “Simon’s first test came back with a score of 70.
Primary age-related tauopathy (PART) is a neuropathological designation introduced in 2014 to describe the neurofibrillary tangles (NFT) that are commonly observed in the brains of normally aged and cognitively impaired individuals that can occur independently of the amyloid plaques of Alzheimer's disease (AD).
Biogen Inc's Alzheimer's drug Aduhelm, approved by U.S. regulators last year for its ability to reduce amyloid brain plaques, also lowers levels of a second protein that accumulates in the brains ...
Florbetaben, sold under the brand name Neuraceq, is a diagnostic radiotracer developed for routine clinical application to visualize β-amyloid plaques in the brain. It is a fluorine-18 (18 F)-labeled stilbene derivative. Florbetaben was approved for medical use in the European Union, the United States, and South Korea in 2014.
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