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Minoxidil is a prodrug that is converted by sulfation via the sulfotransferase enzyme SULT1A1 to its active form, minoxidil sulfate. The effect of minoxidil is mediated by adenosine, which triggers intracellular signal transduction via both adenosine A1 receptors and two sub-types of adenosine A2 receptors (A 2A and A 2B receptors). [26]
The 5% minoxidil worked quicker than the 2% minoxidil treatment. There was one downside, though. The men who used the 5% treatment had more side effects, like itching and irritation, than those ...
Medications like diuretics and antidepressants can increase the blood pressure-lowering effects of minoxidil. However, interactions are more likely with oral minoxidil than topical minoxidil.
Using ones own cells and tissues and without harsh side effects, PRP is beneficial for alopecia areata [48] and androgenetic alopecia and can be used as an alternative to minoxidil or finasteride. [49] It has been documented to improve hair density and thickness in both genders. [50]
Oral minoxidil is typically used to treat hypertension, or high blood pressure. Although it hasn’t been approved by the FDA to treat hair loss, it’s sometimes prescribed off-label at low doses ...
Minoxidil sulfate is formed from minoxidil via sulfotransferase enzymes, with the predominant enzyme responsible, at least in hair follicles, being SULT1A1. [1] [2] Minoxidil sulfate acts as a potassium channel opener, among other actions, and has vasodilating, hypotensive, and trichogenic or hypertrichotic (hair growth-promoting) effects.
A 2023 study comparing the efficacy and safety of 1-milligram daily oral minoxidil and 5% topical minoxidil found that topical minoxidil had a better therapeutic effect (meaning it worked a little ...
As you can imagine, the side effects of minoxidil differ depending on whether you’re using an oral or topical version. ... there are some possible side effects, including: Low blood pressure.