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The ability of the immune system to recognize molecules that are broadly shared by pathogens is, in part, due to the presence of immune receptors called toll-like receptors (TLRs) that are expressed on the membranes of leukocytes including dendritic cells, macrophages, natural killer cells, cells of the adaptive immunity T cells, and B cells, and non-immune cells (epithelial and endothelial ...
The first function described for TLR4 was the recognition of exogenous molecules from pathogens (PAMPs), in particular LPS molecules from gram-negative bacteria. [13] As pattern recognition receptor, TLR4 plays a fundamental role in pathogen recognition and activation of innate immunity which is the first line of defense against invading micro-organisms.
Recognition of extracellular or endosomal pathogen-associated molecular patterns is mediated by transmembrane proteins known as toll-like receptors (TLRs). [7] TLRs share a typical structural motif, the leucine rich repeats (LRR), which give them their specific appearance and are also responsible for TLR functionality. [8]
Toll-like receptor 7, also known as TLR7, is a protein that in humans is encoded by the TLR7 gene. Orthologs are found in mammals and birds. [ 5 ] It is a member of the toll-like receptor (TLR) family and detects single stranded RNA.
Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a protein that in humans is encoded by the TLR3 gene. [5] TLR3 is a member of the toll-like receptor family of pattern recognition receptors of the innate immune system .
Toll-like receptor 9 is a protein that in humans is encoded by the TLR9 gene. [5] TLR9 has also been designated as CD289 ( cluster of differentiation 289). It is a member of the toll-like receptor (TLR) family.
Comparison of different receptor targets and associated functions Receptor Bind to [1] Function [1]; Pattern recognition receptors (PRRs) (e.g. TLRs, NLRs) Pathogen-associated molecular patterns (PAMP)
A TLR3 agonist is a molecule that activates TLR3 mediated immune response. Pages in category "TLR3 agonist" The following 2 pages are in this category, out of 2 total.