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The effects of tamoxifen on breast cancer Ki-67 expression, sex hormone-binding globulin (SHBG) levels, and IGF-1 levels are dose-dependent across a dosage range of 1 to 20 mg/day in women with breast cancer. [84] Tamoxifen has been found to decrease insulin-like growth factor 1 (IGF-1) levels by 17 to 38% in women and men. [85]
The hydroxyl group is of particular importance for ER binding of 4-hydroxytamoxifen, and the ethyl side chain of tamoxifen protrudes out of the ligand-binding domain of the ER. [27] Few tamoxifen users have had increased rates of uterine cancer, hot flushes, and thromboembolisms. The drug can also cause hepatocarcinomas in rats.
The side effects of toremifene are similar to those of tamoxifen. [5] The most common side effect is hot flashes. [5] Other side effects include sweating, nausea, vomiting, dizziness, vaginal discharge, and vaginal bleeding. [5] [7] In women with bone metastases, hypercalcemia may occur. [5] Toremifene has a small risk of thromboembolic events. [5]
Breast cancer predominantly affects women; less than 1% of those with breast cancer are men. [158] Women can develop breast cancer as early as adolescence, but risk increases with age, and 75% of cases are in women over 50 years old. [158] The risk over a woman's lifetime is approximately 1.5% at age 40, 3% at age 50, and more than 4% risk at ...
One of the largest breast cancer prevention studies ever, [2] it included 22,000 women in 400 medical centers in the United States and Canada. [3] [4] [5] The study concluded that raloxifene caused fewer side-effects and less endometrial cancer than tamoxifen.
In addition to these findings, researchers also found that the brain-protective effects of more dietary magnesium appeared to benefit women more than men, and more so in post-menopausal than pre ...
There are conflicting reports on the effects of combined birth control pills on sexual function in women. [60] Progestogen-only birth control , such as with depot medroxyprogesterone acetate or the etonogestrel birth control implant , has shown mixed effects on sexual desire and function.
Pasquale Rotella, CEO of Insomniac events — which puts on big-name EDM festivals like Electric Daisy Carnival — agreed with Yousaf, telling HuffPost that there’s simply more men on the production side of EDM. “There are a lot of female agents, managers and publicists in the industry but most of them are pushing male artists,” he said.
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