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The evLYG measures the cost of a treatment per life year gained regardless of the quality of life provided by that treatment. [12] ... multiple sclerosis, PCSK9 ...
Treatments for quadriplegics, patients with multiple sclerosis, or other disabilities are valued less under a QALY-based system. [32] Critics also argue that a QALY-based system would limit research on treatments for rare disorders because the upfront costs of the treatments tend to be higher.
Exacerbations rarely occur more frequently than twice per year. [1] Some relapses, however, ... Deaths from multiple sclerosis per million persons in 2012
In March 2017, ocrelizumab was approved in the United States for the treatment of primary progressive multiple sclerosis in adults. [22] [42] It is also used for the treatment of relapsing forms of multiple sclerosis, to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease in adults. [42]
In the United States, as of 2015, the cost is between US$1,284 and US$1,386 per 30 mcg vial. [31] As of 2020, the National Average Drug Acquisition Cost (NADAC) in the United States for Avonex was $6,872.94 for a 30 mcg kit. [32] Avonex and Rebif are on the top ten best-selling multiple sclerosis drugs of 2013. [33]
Treatment in MS Phase III studies is usually two years per patient. In July 2021, the FDA gave the go-ahead for an investigational new drug application (IND) for the phase 3 ENSURE program, which will evaluate IMU-838 in patients with relapsing-remitting multiple sclerosis (RRMS).
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