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A GABA reuptake inhibitor (GRI) is a type of drug which acts as a reuptake inhibitor for the neurotransmitter gamma-Aminobutyric acid (GABA) by blocking the action of the gamma-Aminobutyric acid transporters (GATs). This in turn leads to increased extracellular concentrations of GABA and therefore an increase in GABAergic neurotransmission. [1]
In pharmacology, GABA A receptor positive allosteric modulators, also known as GABAkines or GABA A receptor potentiators, [1] are positive allosteric modulator (PAM) molecules that increase the activity of the GABA A receptor protein in the vertebrate central nervous system. GABA is a major inhibitory neurotransmitter in the central nervous system.
[36] [37] [38] Although the term "GABA С receptor" is frequently used, GABA С may be viewed as a variant within the GABA A receptor family. [7] Others have argued that the differences between GABA С and GABA A receptors are large enough to justify maintaining the distinction between these two subclasses of GABA receptors.
Like other GABA-T inhibitors, γ-acetylenic GABA causes GABA levels in the brain to be elevated. This is due to 4-aminobutyrate transaminase being the enzyme that converts γ-aminobutyric acid to L-glutamate. Inhibiting the enzyme stops this conversion from happening.
Treatment The primary treatment for atherosclerosis is making lifestyle changes to help prevent the further build-up of plaque in your blood vessels. You may also need to take medications or ...
The ionotropic GABA A receptor protein complex is also the molecular target of the benzodiazepine class of tranquilizer drugs. Benzodiazepines do not bind to the same receptor site on the protein complex as does the endogenous ligand GABA (whose binding site is located between α- and β-subunits), but bind to distinct benzodiazepine binding sites situated at the interface between the α- and ...
The federal Centers for Diseases Control reports that 91 men in the World Trade Center Health Program have been diagnosed with breast cancer to date, six times the number The Post first reported ...
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