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Tamoxifen was initially made in 1962, by chemist Dora Richardson. [17] [18] It is on the World Health Organization's List of Essential Medicines. [19] Tamoxifen is available as a generic medication. [14] In 2020, it was the 317th most commonly prescribed medication in the United States, with more than 900 thousand prescriptions. [20] [21]
The incidence of liver damage from herbal and dietary supplements is about 16–20% of all supplement products causing injury, with the occurrence growing globally over the early 21st century. [2] The most common liver injuries from weight loss and bodybuilding supplements involve hepatocellular damage and jaundice.
About 20% of males and 17% of females will get cancer at some point in time while 13% of males and 9% of females will die from it. [ 209 ] In 2008, approximately 12.7 million cancers were diagnosed (excluding non-melanoma skin cancers and other non-invasive cancers) [ 24 ] and in 2010 nearly 7.98 million people died. [ 210 ]
Windows NT 3.1 is the first major release of the Windows NT operating system developed by Microsoft, released on July 27, 1993.It marked the company's entry into the corporate computing environment, designed to support large networks and to be portable, compiled for Intel x86, DEC Alpha and MIPS based workstations and servers. [3]
Zero coupon bonds have a duration equal to the bond's time to maturity, which makes them sensitive to any changes in the interest rates. Investment banks or dealers may separate coupons from the principal of coupon bonds, which is known as the residue, so that different investors may receive the principal and each of the coupon payments.
In finance, a coupon is the interest payment received by a bondholder from the date of issuance until the date of maturity of a bond. [1] Coupons are normally described in terms of the "coupon rate", which is calculated by adding the sum of coupons paid per year and dividing it by the bond's face value. [2]