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The plasma membrane monoamine transporter ( PMAT) is a low-affinity monoamine transporter protein which in humans is encoded by the SLC29A4 gene. [1] It is known alternatively as the human equilibrative nucleoside transporter-4 (hENT4). It was discovered in 2004 [2] and has been identified as a potential alternate target for treating various ...
Monoamine transporters ( MATs) are proteins that function as integral plasma-membrane transporters to regulate concentrations of extracellular monoamine neurotransmitters. The three major classes are serotonin transporters (SERTs), dopamine transporters (DATs), and norepinephrine transporters (NETs) and are responsible for the reuptake of their ...
hide. PMAT may refer to: Plasma membrane monoamine transporter (PMAT) Four phases of mitosis: prophase, metaphase, anaphase, and telophase. Prophase: Chromatin into chromosomes, the nuclear envelope break down, chromosomes attach to spindle fibres by their centromeres. Metaphase: Chromosomes line up along the metaphase plate (centre of the cell).
A serotonin–norepinephrine–dopamine reuptake inhibitor ( SNDRI ), also known as a triple reuptake inhibitor ( TRI ), is a type of drug that acts as a combined reuptake inhibitor of the monoamine neurotransmitters serotonin, norepinephrine, and dopamine. It does this by concomitantly inhibiting the serotonin transporter (SERT ...
The vesicular monoamine transporter (VMAT) is a transport protein integrated into the membranes of synaptic vesicles of presynaptic neurons. It transports monoamine neurotransmitters – such as dopamine, serotonin, norepinephrine, epinephrine, and histamine – into the vesicles, which release the neurotransmitters into synapses, as chemical ...
In cells stably expressing PMAT and SERT, the apparent affinity of recombinant PMAT for 5-HT is much lower than that of SERT (Km, 114 v.s. 0.5 μM) [12, 15]. However, PMAT also has a much larger transport capacity (Vmax), resulting in roughly comparable uptake efficiencies (Vmax/Km) to SERT in heterologous expression systems
Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C 5 H 4 N 4 O 3. It forms ions and salts known as urates and acid urates, such as ammonium acid urate. Uric acid is a product of the metabolic breakdown of purine nucleotides, and it is a normal component of urine. [ 1]
Pemetrexed is also recommended in combination with carboplatin and pembrolizumab for the first-line treatment of advanced non-small cell lung cancer. [12] [13] However, the relative efficacy or toxicity of pemetrexed-cisplatin versus pemetrexed-carboplatin has not been established beyond what is generally thought about cisplatin or carboplatin doublet drug therapy.