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Management of multiple sclerosis. Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease that affects the central nervous system (CNS). Several therapies for it exist, although there is no known cure. The most common initial course of the disease is the relapsing-remitting subtype, which is characterized by unpredictable ...
Fingolimod was approved and released on the market in USA in 2010 as an anti-multiple sclerosis drug. [10] Multiple sclerosis is an autoimmune disease where immune cells attack the neurons of the central nervous system and degrade the myelin that protect them. [11] There is no cure for multiple sclerosis, but disease modifying therapies (DMTs ...
[15] [16] [8] [17] MS is usually diagnosed based on the presenting signs and symptoms and the results of supporting medical tests. [5] No cure for multiple sclerosis is known. [18] Current treatments are aimed at mitigating inflammation and resulting symptoms from acute flares and prevention of further attacks with disease-modifying medications.
In the United states, natalizumab is indicated for the treatment of multiple sclerosis and Crohn's disease. [1] [9] It is indicated to treat clinically isolated syndrome – a single, first occurrence of multiple sclerosis symptoms; relapsing-remitting disease – a type of multiple sclerosis that occurs when people have episodes of new neurological symptoms followed by periods of stability ...
Interferon beta-1a (also interferon beta 1-alpha) is a cytokine in the interferon family used to treat multiple sclerosis (MS). [ 5] It is produced by mammalian cells, while interferon beta-1b is produced in modified E. coli. [ 6] Some research indicates that interferon injections may result in an 18–38% reduction in the rate of MS relapses.
In September 2010, fingolimod became the first oral disease-modifying drug approved by the U.S. Food and Drug Administration (FDA) to reduce relapses and delay disability progression in patients with relapsing forms of multiple sclerosis. [28] [29] In April 2011 Novartis said that the drug would be available in Canadian pharmacies.
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