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The optic vesicles project toward the sides of the head, and the peripheral part of each expands to form a hollow bulb, while the proximal part remains narrow and constitutes the optic stalk. [1] [2] Closure of the choroidal fissure in the optic stalk occurs during the seventh week of development. The former optic stalk is then called the optic ...
The eyes begin to develop as a pair of diverticula (pouches) from the lateral aspects of the forebrain.These diverticula make their appearance before the closure of the anterior end of the neural tube; [1] [2] after the closure of the tube around the 4th week of development, they are known as the optic vesicles.
The optic vesicles then develop into the optic cup with the inner layer forming the retina and the outer portion forming the retinal pigment epithelium. The middle portion of the optic cup develops into the ciliary body and iris. [7] During the invagination of the optic cup, the ectoderm begins to thicken and form the lens placode, which ...
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The lens placode under the direction of the optic vesicle gives rise to the lens of the eye. The adenohypophyseal placode , which forms the anterior lobe of the pituitary gland . Other animals
Invagination is the process of folding in cells. The lens placode invaginates to later develop the lens or lens pit. The development of the lens placode is typically seen between 44 and 50 hours; invagination occurs shortly after at around the 50–55-hour mark.
PAX6 is essential is the formation of the retina, lens and cornea due to its role in early cell determination when forming precursors of these structures such as the optic vesicle and overlying surface ectoderm. [20]
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