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Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. [1] There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity.
Proper kidney function depends upon adequate blood flow to the kidney. Kidney blood flow is a complex, tightly regulated process that relies on a number of hormones and other small molecules, such as prostaglandins. Under normal circumstances, prostaglandin E2 (PGE 2) produced by the kidney is necessary to support adequate blood flow to the kidney.
The US prescribing information lists the following drug interactions for valsartan: Other inhibitors of the renin-angiotensin system may increase the risks of low blood pressure, kidney problems, and hyperkalemia. Potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium may increase the risk of hyperkalemia.
After an average follow-up of about 3.5 years, scientists discovered that adverse kidney-related events — such as a significant decline in kidney function, death from kidney causes, or onset of ...
Standard measures to maintain normal urine output should be instituted and kidney function monitored. [47] Since ibuprofen has acidic properties and is also excreted in the urine, forced alkaline diuresis is theoretically beneficial. However, because ibuprofen is highly protein-bound in the blood, the kidneys' excretion of the unchanged drug is ...
These drugs work by mimicking GLP-1, a hormone naturally produced in the intestines. ... vomiting, or diarrhea, which can lead to dehydration and affect kidney function.
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