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C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentrations rise in response to inflammation. It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells .
EXCERPT: Activated leukocytes induce the synthesis and secretion from the liver of an unrelated set of proteins called acute-phase proteins. One such protein, C-reactive protein (CRP) was originally identified as binding to the phosphocholine attachment site of capsular polysaccharide (C-polysaccharide) from Streptococcus pneumoniae.
Positive acute-phase proteins serve (as part of the innate immune system) different physiological functions within the immune system.Some act to destroy or inhibit growth of microbes, e.g., C-reactive protein, mannose-binding protein, [3] complement factors, ferritin, ceruloplasmin, serum amyloid A and haptoglobin.
C1q can also be activated in other ways, for example by binding to pentraxins such as C-reactive protein [2] or directly to the surface of pathogens. [ 1 ] Such binding of C1q leads to conformational changes in the C1q molecule, which activates the associated C1r molecules.
Patricia Foster, PhD, is a Professor Emerita of Biology at Indiana University Bloomington. ... Plus, having type O blood also doesn’t automatically mean you’re going to get norovirus; after ...
It is also one of the binding targets of C-reactive protein (CRP). [3] Thus, when a cell is damaged, CRP binds to phosphocholine, beginning the recognition and phagocytotic immunologic response. Phosphocholine is a natural constituent of hens' eggs (and many other eggs) often used in biomimetic membrane studies.
Not only does testosterone affect many physiological processes, but it can also have an impact on cognitive function and mood. If you have low testosterone, you may have a higher risk of ...
President Biden acknowledged concerns about his age, stamina and ability to have served a second term in an interview with USA Today in the Oval Office.