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Propentofylline was studied as a possible treatment for Alzheimer's disease and multi-infarct dementia, [1] [4] and has been studied, to a lesser extent, as a possible adjunct in the treatment of ischemic stroke, due to its vasodilating properties. [5] [6] Propentofylline is in use as a veterinary medicine in older dogs. [7]
Canine cognitive dysfunction (CCD) is a disease prevalent in dogs that exhibit symptoms of dementia or Alzheimer's disease shown in humans. [1] CCD creates pathological changes in the brain that slow the mental functioning of dogs resulting in loss of memory, motor function, and learned behaviors from training early in life.
The AKC reports that one study found that 28% of dogs between 11 and 12 years of age have at least one sign of dog dementia, and that increased to 68% in dogs over 15 years of age.
Geriatric dogs treated with selegiline show improvements in sleeping pattern, reduced urinary incontinence, and increased activity level, with most showing improvements by one month of treatment. [ 303 ] [ 304 ] Though it is labeled for use in dogs only, selegiline has been used off-label for geriatric cats with cognitive dysfunction .
A recent study found that a class of medications called SGLT-2 inhibitors—which does not include Ozempic or similar drugs like Zepbound—significantly lowered the risk of dementia in people ...
Dogs and people can reduce their risk of dementia by walking and other exercise. Symptoms of dog dementia include pacing, failing to recognize familiar people. Dogs get dementia, too.
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