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free Kt/V calculators, single pool and equilibrated HD, PD, no login needed, site used by dozens of dialysis centers around the world for over 10 years – kt-v.net Web/javascript program that does formal 2-pool urea kinetics in multiple patients – ureakinetics.org
Standardized Kt/V, also std Kt/V, is a way of measuring dialysis adequacy. It was developed by Frank Gotch and is used in the United States to measure dialysis. Despite the name, it is quite different from Kt/V. In theory, both peritoneal dialysis and hemodialysis can be quantified with std Kt/V.
Since the URR and Kt/V are so closely related, their predictive power in terms of patient outcome is similar. However, use of Kt/V and urea modeling in general allows for comparing expected with predicted dose of dialysis, which can be used to analyze dialysis treatments and dialyzer clearances and in troubleshooting and quality control ...
The heavy green line shows the relation when UF/W - 0.03. So in practice, because of urea generation and UF/W, a 63% URR (0.63) results in a Kt/V of about 1.15 instead of only 1.0 (see graph). KDOQI hemodialysis adequacy standards are written in terms of either Kt/V or URR, with Kt/V being the preferred choices. But a patient may meet one ...
Diagram showing the basic physiologic mechanisms of the kidney. The renal clearance ratio or fractional excretion is a relative measure of the speed at which a constituent of urine passes through the kidneys.
The functions of the kidney include maintenance of acid-base balance; regulation of fluid balance; regulation of sodium, potassium, and other electrolytes; clearance of toxins; absorption of glucose, amino acids, and other small molecules; regulation of blood pressure; production of various hormones, such as erythropoietin; and activation of vitamin D.
Hemodialysis product (HDP) - is a number used to quantify hemodialysis and peritoneal dialysis treatment adequacy. It was proposed by Scribner and Oreopoulous because of their perceived inadequacy of the Kt/V measure of dialysis adequacy. The HDP is defined by the following empirical formula: HDP = t * f 2. Where: HDP - hemodialysis product
t is dialysis time or time since injection of the substance/drug [min] or [s] V is the volume of distribution or total body water [L] or [m 3] K is the clearance [mL/min] or [m 3 /s] C is the concentration [mmol/L] or [mol/m 3] (in the United States often [mg/mL])