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Lamotrigine has fewer drug interactions than many anticonvulsant drugs, although pharmacokinetic interactions with carbamazepine, phenytoin and other hepatic enzyme-inducing medications may shorten half-life. [83] Dose adjustments should be made on clinical response, but monitoring may be of benefit in assessing compliance. [5]
Japanese encephalitis vaccines first became available in the 1930s. [3] One of them was an inactivated mouse brain-derived vaccine (the Nakayama and/or Beijing-1 strain), made by BIKEN and marketed by Sanofi Pasteur as JE-VAX, until production ceased in 2005.
Sanofi's drug, a monoclonal antibody, was discovered by Regeneron Pharmaceuticals and is called alirocumab. [126] An FDA warning in March 2014, about possible cognitive adverse effects of PCSK9 inhibition threw the competition into disarray, as the FDA asked companies to include neurocognitive testing into their Phase III clinical trials. [127]
The higher the dosage and the longer the drug is taken, the greater the risk of experiencing unpleasant withdrawal symptoms. Benzodiazepine treatment should only be discontinued via a slow and gradual dose reduction regimen.
Controversially, some psychiatric ward patients may be given Chlorpromazine by force, even if they do not suffer any of the typical conditions the drug is prescribed for. [13] In a 2013 comparison of fifteen antipsychotics in schizophrenia, chlorpromazine demonstrated mild-standard effectiveness.
Sanofi quoted Houman Ashrafian, its head of research and development, as saying that it "represents an unprecedented breakthrough as a potential first-in-disease treatment option with clinically ...
The preceding drug and food contraindications are dependent on selegiline dose and route, and hence are not necessarily absolute contraindications. [ 4 ] [ 6 ] [ 5 ] [ 7 ] [ 9 ] While high oral doses of selegiline (≥20 mg/day) can cause such interactions, oral doses within the approved clinical range (≤10 mg/day) appear to have little to no ...
In comparison with the smaller dose, finasteride 5mg had a few additional prominent side effects, and a slightly higher severity of the side effects seen in the 1mg dose.