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A liposome is a small artificial vesicle, spherical in shape, having at least one lipid bilayer. [2] Due to their hydrophobicity and/or hydrophilicity, biocompatibility, particle size and many other properties, [ 2 ] liposomes can be used as drug delivery vehicles for administration of pharmaceutical drugs and nutrients , [ 3 ] such as lipid ...
Additionally, negative staining transmission electron microscopy has been shown as a useful tool to study lipid bilayer phase behavior and polymorphism into lamellar phase, micellar, unilamellar liposome, and hexagonal aqueous-lipid structures, in aqueous dispersions of membrane lipids. [2]
(Note- the term “liposome” is in essence synonymous with “vesicle” except that vesicle is a general term for the structure whereas liposome refers to only artificial not natural vesicles) The basic idea of liposomal drug delivery is that the drug is encapsulated in solution inside the liposome then injected into the patient. These drug ...
Galactolipids – monogalactosyl diglyceride (MGDG) and digalactosyl diglycreride (DGDG) form the predominant lipids in higher plant chloroplast thylakoid membranes; liposomal structures formed by total lipid extract of thylakoid membranes have been found sensitive to sucrose as it turns bilayers into micellar structures.
The PTX-embedded cationic liposome interacts with the negatively charged tumor endothelial cells required for tumor angiogenesis, in order to reduce their tumor blood supply. [ 7 ] [ 16 ] Through this mechanism, EndoTAG-1 is able to prevent angiogenesis in the tumor, which in turn inhibits tumor growth. [ 16 ]
First, the involved membranes must aggregate, approaching each other to within several nanometers. Second, the two bilayers must come into very close contact (within a few angstroms). To achieve this close contact, the two surfaces must become at least partially dehydrated, as the bound surface water normally present causes bilayers to strongly ...
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A unilamellar liposome is a spherical liposome, a vesicle, ... of biological functions. [10] These encapsulation methods include microfluidic methods, which allow for ...
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