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Additionally, negative staining transmission electron microscopy has been shown as a useful tool to study lipid bilayer phase behavior and polymorphism into lamellar phase, micellar, unilamellar liposome, and hexagonal aqueous-lipid structures, in aqueous dispersions of membrane lipids. [2]
A liposome is a small artificial vesicle, spherical in shape, having at least one lipid bilayer. [2] Due to their hydrophobicity and/or hydrophilicity, biocompatibility, particle size and many other properties, [ 2 ] liposomes can be used as drug delivery vehicles for administration of pharmaceutical drugs and nutrients , [ 3 ] such as lipid ...
The PTX-embedded cationic liposome interacts with the negatively charged tumor endothelial cells required for tumor angiogenesis, in order to reduce their tumor blood supply. [ 7 ] [ 16 ] Through this mechanism, EndoTAG-1 is able to prevent angiogenesis in the tumor, which in turn inhibits tumor growth. [ 16 ]
A unilamellar liposome is a spherical liposome, a vesicle, bounded by a single bilayer of an amphiphilic lipid or a mixture of such lipids, ...
A ligand-targeted liposome (LTL) is a nanocarrier with specific ligands attached to its surface to enhance localization for targeted drug delivery. The targeting ability of LTLs enhances cellular localization and uptake of these liposomes for therapeutic or diagnostic purposes.
The three main structures phospholipids form in solution; the liposome (a closed bilayer), the micelle and the bilayer. [1] The lipid bilayer (or phospholipid bilayer) is a thin polar membrane made of two layers of lipid molecules. These membranes are flat sheets that form a continuous barrier around all cells.
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Surprisingly, liposomal fatty acyl chains are more restricted at 5th and 7th carbon positions as compared at these positions in thylakoid membranes. This is explainable as due to motional restricting effect at these positions, because of steric hindrance by large chlorophyll headgroups, specially so, in liposomes.