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New drugs to treat debilitating menopause symptoms — namely hot flashes — are ... Those drugs can include off-label use of the pain medication gabapentin or an antidepressant sold as Effexor.
Venlafaxine, sold under the brand name Effexor among others, is an antidepressant medication of the serotonin–norepinephrine reuptake inhibitor (SNRI) class. [ 6 ] [ 9 ] It is used to treat major depressive disorder , generalized anxiety disorder , panic disorder , and social anxiety disorder . [ 9 ]
For example, venlafaxine works alongside its primary metabolite O-desmethylvenlafaxine to strongly inhibit serotonin and norepinephrine reuptake in the brain. The evidence also suggests that dopamine and norepinephrine behave in a co-transportational manner, due to the inactivation of dopamine by norepinephrine reuptake in the frontal cortex ...
Desvenlafaxine is a synthetic form of the isolated major active metabolite of venlafaxine, and is categorized as a serotonin-norepinephrine reuptake inhibitor (SNRI). When most normal metabolizers take venlafaxine, approximately 70% of the dose is metabolized into desvenlafaxine, so the effects of the two drugs are expected to be very similar. [18]
Escitalopram. Escitalopram, sold under the name Lexapro, is most commonly used to treat depression and generalized anxiety disorder (GAD). According to a 2018 review, escitalopram is one of the ...
A follow-up study to the Women’s Health Initiative finds that hormone replacement therapy is beneficial for women in menopause. The therapy can help relieve symptoms like hot flashes and night ...
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