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The packaging for valsartan includes a warning stating the drug should not be used with the renin inhibitor aliskiren in people with diabetes. It also states the safety of the drug in severe renal impairment has not been established. [7] Valsartan includes a black box warning for fetal toxicity.
Developmental toxicity is any developmental malformation that is caused by the toxicity of a chemical or pathogen. It is the structural or functional alteration, reversible or irreversible, which interferes with homeostasis , normal growth , differentiation , development or behavior.
The use of valsartan in pregnancy is avoided due to the potential risk of fetal toxicity. [11] The U.S. Food and Drug Administration has a black box warning for valsartan/hydrochlorothiazide use during pregnancy. [2] The use of hydrochlorothiazide is avoided in those with anuria or severe kidney disease. [12]
War Zone C was the area in South Vietnam centered around the abandoned town of Katum near the Cambodian border where there was a strong concentration of People's Army of Vietnam (PAVN) and Viet Cong (VC) activity during the Vietnam War.
The problem, he said, is that “war will break these values. “There is an inherent contradiction between the warrior code, how these guys define themselves, what they expect of themselves – to be heroes, the selfless servants who fight for the rest of us – and the impossibility in war of ever living up to those ideals. It cannot be done.
The Tarnak Farm incident is the killing, by an American Air National Guard pilot, of four Canadian soldiers and the injury of eight others from the 3rd Battalion, Princess Patricia's Canadian Light Infantry Battle Group (3PPCLIBG) on the night of April 17, 2002, near Kandahar, Afghanistan.
Unit 731 (Japanese: 731部隊, Hepburn: Nana-san-ichi Butai), [note 1] short for Manchu Detachment 731 and also known as the Kamo Detachment [3]: 198 and the Ishii Unit, [5] was a covert biological and chemical warfare research and development unit of the Imperial Japanese Army that engaged in lethal human experimentation and biological weapons manufacturing during the Second Sino-Japanese War ...
Environmental toxicants and fetal development is the impact of different toxic substances from the environment on the development of the fetus. This article deals with potential adverse effects of environmental toxicants on the prenatal development of both the embryo or fetus, as well as pregnancy complications. The human embryo or fetus is ...