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  2. Kynurenine pathway - Wikipedia

    en.wikipedia.org/wiki/Kynurenine_pathway

    Also known as kynureninase deficiency, this extremely rare inherited disorder is caused by the defective enzyme kynureninase which leads to a block in the pathway from tryptophan to niacin (nicotinic acid). As a result, tryptophan is no longer a source of niacin, hence leading to pellagra (niacin deficiency).

  3. Vitamin deficiency - Wikipedia

    en.wikipedia.org/wiki/Vitamin_deficiency

    Niacin deficiency is a consequence of a diet low in both niacin and the amino acid tryptophan, a precursor for the vitamin. Low plasma tryptophan is a non-specific indicator, meaning it can have other causes. The signs and symptoms of niacin deficiency start to revert within days of oral supplementation with large amounts of the vitamin. [23] [24]

  4. Pellagra - Wikipedia

    en.wikipedia.org/wiki/Pellagra

    Carcinoid syndrome thus may produce niacin deficiency and clinical manifestations of pellagra. Anti-tuberculosis medication tends to bind to vitamin B 6 and reduce niacin synthesis, since B 6 (pyridoxine) is a required cofactor in the tryptophan-to-niacin reaction. Several therapeutic drugs can provoke pellagra.

  5. Excess amounts of this B vitamin linked to higher heart ...

    www.aol.com/excess-amounts-b-vitamin-linked...

    About 1 in 4 Americans have too much niacin in their body from eating meats and nuts, ... But even though niacin deficiency is a rarity in the U.S., some people do take it as a dietary supplement ...

  6. Niacin - Wikipedia

    en.wikipedia.org/wiki/Niacin

    A man with pellagra, which is caused by a chronic lack of vitamin B 3 in the diet. Severe deficiency of niacin in the diet causes the disease pellagra, characterized by diarrhea, sun-sensitive dermatitis involving hyperpigmentation and thickening of the skin (see image), inflammation of the mouth and tongue, delirium, dementia, and if left untreated, death. [7]

  7. Another rare bird is spotted in Ohio. Meet the black-bellied ...

    www.aol.com/another-rare-bird-spotted-ohio...

    In a Facebook post this week, the Ohio Division of Wildlife reports that black-bellied whistling-ducks have been spotted with ducklings at a wildlife area in Wayne County, northwest of Tuscarawas ...

  8. Nicotinamide riboside - Wikipedia

    en.wikipedia.org/wiki/Nicotinamide_riboside

    Pellagra was the first disease to be associated with NAD+ deficiency. [12] It was linked to nutritional deficiency by Joseph Goldberger in 1914, and to deficiency of niacin (vitamin B 3) by Conrad Elvehjem in 1937. NAD+ (then called coenzyme I) was shown to be extremely low in cases of pellagra, and NA and NAM were identified as molecular ...

  9. Navy wife goes viral for surprising husband with hunting trip ...

    www.aol.com/navy-wife-goes-viral-surprising...

    A woman in Kentucky surprised her Navy husband with a special military homecoming by gifting him a five-day duck hunting trip in Kansas with his best friends ahead of Christmas.