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The role of clozapine in treatment-resistant schizophrenia was established by a 1988 landmark multicenter double blind study [42] in which clozapine (up to 900 mg/d) showed marked benefits compared to chlorpromazine (up to 1800 mg/d) in a group of patients with protracted psychosis who had already shown an inadequate response to at least three ...
Hypersalivation can contribute to drooling if there is an inability to keep the mouth closed or difficulty in swallowing (dysphagia) the excess saliva, which can lead to excessive spitting. Hypersalivation also often precedes emesis (vomiting), where it accompanies nausea (a feeling of needing to vomit).
[149] [150] Clozapine is of benefit to around half of this group although it has the potentially serious side effect of agranulocytosis (lowered white blood cell count) in less than 4% of people. [151] [152] [153] Between 12 and 20 per cent will not respond to clozapine and this group is said to have ultra treatment resistant schizophrenia.
Clozapine-induced drooling; Bowel colic; Eye inflammation [28] It is sometimes used as a premedication, especially to reduce respiratory tract secretions in surgery, most commonly by injection. [22] [23] Common side effects include sleepiness, blurred vision, dilated pupils, and dry mouth. [1]
And yet for those who take clozapine, REMS requires "weekly blood tests for the first 6 months" on the drug, testing "every 2 weeks for the next 6 months" if tests are normal, and "monthly after ...
Villanueva had arrived at an Indiana hospital at 41 weeks to have her labor induced. To ease the pain of her contractions, doctors gave her narcotics. A day later, a social worker told the new ...
Clozapine is associated with side effects that include weight gain, tiredness, and hypersalivation. More serious adverse effects include seizures , NMS, neutropenia , and agranulocytosis (lowered white blood cell count) and its use needs careful monitoring.
Gradually, treatment was helping remove the cancer. I also mixed in some holistic interventions, too, and slowly got back to myself. Now, I’m healthy. I spent what feels like ages doing various ...