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Thiomalic acid is an intermediate in the synthesis of corrosion inhibitors, soil fumigants, active pharmaceutical ingredients, and electroplating agents. [1] The sodium and gold salt of thiomalic acid, sodium aurothiomalate, is used as a pharmaceutical drug for the treatment of rheumatoid arthritis. [2]
Succimer is an isomer of 2,3-dimercaptosuccinic acid. 2,3-dimercaptosuccinic acid is the organosulfur compound with the formula HO 2 CCH(SH)CH(SH)CO 2 H. This colorless solid contains two carboxylic acid and two thiol groups, the latter being responsible for its mildly unpleasant odour.
Thioglycolic acid with a pK a of 3.83 [7] is an acid about 8.5 times stronger than acetic acid (pK a 4.76): HSCH 2 CO 2 H → HSCH 2 CO 2 − + H + The second ionization has a pK a of 9.3: HSCH 2 CO 2 − → − SCH 2 CO 2 − + H + Thioglycolic acid is a reducing agent, especially at higher pH.
The name mercapturic acid is a combination of mercapturic and acid. The latter indicates that the compound is an acid. The former is a compound word consisting of the stem mercaptur-, coming from mercaptan, and the suffix-ic, meaning "having the character of". In sum, the name mercapturic acid means "an acid with mercaptan character/nature". [6]
mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function by inhibiting the mammalian target of rapamycin (mTOR) (also known as the mechanistic target of rapamycin), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases ...
This list of over 500 monoclonal antibodies includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage. See the list of FDA-approved therapeutic monoclonal antibodies in the monoclonal antibody therapy page.
Monoamine oxidase inhibitors (MAOIs) have a long and prosperous history as medications for major depressive disorder (MDD). But this type of antidepressant has mostly seen its day. 4 FDA-Approved ...
Dactolisib (codenamed NVP-BEZ235 and BEZ-235, also known as RTB101) is an imidazoquinoline derivative acting as a PI3K inhibitor. [1] It also inhibits mTOR. [2] It is being investigated as a possible cancer treatment. [3] It has been shown to be toxic to Waldenström's macroglobulinemia cells. [4]
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