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Thiomalic acid or mercaptosuccinic acid is a dicarboxylic acid containing a thiol functional group. As suggested by its name, it contains a thiol group (SH) in place of the hydroxy group (OH) in malic acid .
Succimer is an isomer of 2,3-dimercaptosuccinic acid. 2,3-dimercaptosuccinic acid is the organosulfur compound with the formula HO 2 CCH(SH)CH(SH)CO 2 H. This colorless solid contains two carboxylic acid and two thiol groups, the latter being responsible for its mildly unpleasant odour.
Thioglycolic acid with a pK a of 3.83 [7] is an acid about 8.5 times stronger than acetic acid (pK a 4.76): HSCH 2 CO 2 H → HSCH 2 CO 2 − + H + The second ionization has a pK a of 9.3: HSCH 2 CO 2 − → − SCH 2 CO 2 − + H + Thioglycolic acid is a reducing agent, especially at higher pH.
In computational biology, protein pK a calculations are used to estimate the pK a values of amino acids as they exist within proteins.These calculations complement the pK a values reported for amino acids in their free state, and are used frequently within the fields of molecular modeling, structural bioinformatics, and computational biology.
Succinic acid (/ s ə k ˈ s ɪ n ɪ k /) is a dicarboxylic acid with the chemical formula (CH 2) 2 (CO 2 H) 2. [5] In living organisms, succinic acid takes the form of an anion, succinate, which has multiple biological roles as a metabolic intermediate being converted into fumarate by the enzyme succinate dehydrogenase in complex 2 of the electron transport chain which is involved in making ...
A common way to synthesize an NHS-activated acid is to mix NHS with the desired carboxylic acid and a small amount of an organic base in an anhydrous solvent. A coupling reagent such as dicyclohexylcarbodiimide (DCC) or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) is then added to form a highly reactive activated acid intermediate.
Fumaric acid is (E)-1,4-but-2-enedioic acid, a trans isomer, whereas maleic acid is the corresponding cis isomer, i.e. (Z)-1,4-but-2-enedioic acid (see cis-trans isomerism). Fumaric acid has pK a values of approximately 3.0 and 4.5. By contrast, maleic acid has pK a values of approximately 1.5 and 6.5.
3-Mercaptopropionic acid (3-MPA) is an organosulfur compound with the formula HSCH 2 CH 2 CO 2 H. It is a bifunctional molecule, containing both carboxylic acid and thiol groups. It is a colorless oil.