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Secondary polycythemia is the most common cause of polycythemia. It occurs in reaction to chronically low oxygen levels , medications, other genetic mutations that impact the body's ability to transport or detect oxygen, or, rarely because of certain cancers.
In oncology, polycythemia vera (PV) is an uncommon myeloproliferative neoplasm in which the bone marrow makes too many red blood cells. [1] The majority of cases [2] are caused by mutations in the JAK2 gene, most commonly resulting in a single amino acid change in its protein product from valine to phenylalanine at position 617.
Symptomatic features of paraneoplastic syndrome cultivate in four ways: endocrine, neurological, mucocutaneous, and hematological.The most common presentation is a fever (release of endogenous pyrogens often related to lymphokines or tissue pyrogens), but the overall picture will often include several clinical cases observed which may specifically simulate more common benign conditions.
Some of these cancer therapies may produce treatment-related, or secondary, symptoms, including: Pain Cancer pain may be caused by the tumor itself compressing nearby structures, impinging on nerves, or causing an inflammatory response. It may also be caused by therapies such as radiation or chemotherapy.
Endometrial cancer is the most common form of cancer of the female reproductive organs in the U.S., with 67,880 new cases diagnosed each year.Over the past decades, rates have increased and ...
Treatment of patients with this POEMS syndrome variant who have evidence of bone lesions and/or myeloma proteins are the same as those for POEMS syndrome patients. In the absence of these features, treatment with rituximab , a monoclonal antibody preparation directed against B cells bearing the CD20 antigen, or siltuximab , a monoclonal ...
The two are distinct genes in that they're on different chromosomes, but they both cause a syndrome called hereditary breast and ovarian cancer syndrome. The prostate and pancreas are now ...
Hyperviscosity syndrome is a group of symptoms triggered by an increase in the viscosity of the blood. Symptoms of high blood viscosity include spontaneous bleeding from mucous membranes , visual disturbances due to retinopathy , and neurologic symptoms ranging from headache and vertigo to seizures and coma .