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Epidemics and pandemics with at least 1 million deaths Rank Epidemics/pandemics Disease Death toll Percentage of population lost Years Location 2 1918 Flu: Influenza A/H1N1: 17–100 million 1–5.4% of global population [4] 1918–1920 Worldwide 2 Plague of Justinian: Bubonic plague 15–100 million 25–60% of European population [5] 541–549
The term pandemic had not been used then, but was used for later epidemics, including the 1918 H1N1 influenza A pandemic—more commonly known as the Spanish flu—which is the deadliest pandemic in history. The most recent pandemics include the HIV/AIDS pandemic, the 2009 swine flu pandemic and the COVID-19 pandemic. Almost all these diseases ...
Human infectious diseases may be characterized by their case fatality rate (CFR), the proportion of people diagnosed with a disease who die from it (cf. mortality rate).It should not be confused with the infection fatality rate (IFR), the estimated proportion of people infected by a disease-causing agent, including asymptomatic and undiagnosed infections, who die from the disease.
COVID-19 is the deadliest pandemic in US history; [360] it was the third-leading cause of death in the US in 2020, behind heart disease and cancer. [361] From 2019 to 2020, US life expectancy dropped by 3 years for Hispanic Americans, 2.9 years for African Americans, and 1.2 years for white Americans. [362]
Such deaths are sometimes evaluated via excess deaths per capita – the COVID-19 pandemic deaths between January 1, 2020, and December 31, 2021, are estimated to be ~18.2 million. Research could help distinguish the proportions directly caused by COVID-19 from those caused by indirect consequences of the pandemic. [60] [61]
The 1918 flu pandemic (Spanish flu) is a deadly pandemic involving the Influenza A virus subtype H1N1 that infected over 500 million people all over the world, predominantly affecting healthy young individuals. [27] [28] Influenza: France (origin, possibly disputed) 1922: Organization
The 1957–1958 Asian flu pandemic was a global pandemic of influenza A virus subtype H2N2 that originated in Guizhou in Southern China. [3] [4] [1] The number of excess deaths caused by the pandemic is estimated to be 1–4 million around the world (1957–1958 and probably beyond), making it one of the deadliest pandemics in history.
Pandemics and their ends are not well-defined, and whether or not one has ended differs according to the definition used. As of 30 December 2024, COVID-19 has caused 7,079,129 [1] confirmed deaths, and 18.2 to 33.5 million estimated deaths. The COVID-19 pandemic ranks as the fifth-deadliest pandemic or epidemic in history. (Full article