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Estrogen also rises during pregnancy, and that, combined with progesterone, can contribute to the formation of melasma, which appears as dark brown spots or patches.
What causes melasma? In short, melasma is a chronic skin condition that appears as darkened areas on the face due to an overproduction of melanin, says Gina Charles , MO, a family physician ...
What is melasma? “Melasma is a skin condition marked by a darkening of the skin, specifically of the face,” says Amy Wechsler, MD, FAAD, a New York City-based, double board-certified ...
The symptoms of melasma are dark, irregular, well-demarcated, hyperpigmented macules to patches. These patches often develop gradually over time. Melasma does not cause any other symptoms beyond the cosmetic discoloration. [4] Patches can vary in size from 0.5 cm (0.2 in) to larger than 10 cm (4 in) depending on the person.
Liver cirrhosis is another cause, though through lowered metabolism of estrogen, not oversecretion or overconsumption like the aforementioned. It's necessary to know there exist two kinds of hyperestrogenism: Absolute (more concentration than usual of estrogen) and relative (a normal concentration of estrogen, higher with respect to progesterone).
Examples of such side effects include breast tenderness and enlargement, nausea, bloating, edema, headache, and melasma. [15] [62] High-dose estrogen therapy with estradiol valerate injections may also cause an increased risk of thromboembolism, changes in blood lipid profile, increased insulin resistance, and increased levels of prolactin. [62]
The exact cause of melasma is unknown, says Dr. Robert Finney, MD, a board-certified dermatologist in New York City. But it’s believed to result from the skin’s pigment-producing cells being ...
There are a wide range of depigmenting treatments used for hyperpigmentation conditions, and responses to most are variable. [11]Most often treatment of hyperpigmentation caused by melanin overproduction (such as melasma, acne scarring, liver spots) includes the use of topical depigmenting agents, which vary in their efficacy and safety, as well as in prescription rules.
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