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The nephron is the minute or microscopic structural and functional unit of the kidney. It is composed of a renal corpuscle and a renal tubule. The renal corpuscle consists of a tuft of capillaries called a glomerulus and a cup-shaped structure called Bowman's capsule. The renal tubule extends from the capsule.
A renal corpuscle (or Malpighian body [1]) is the blood-filtering component of the nephron of the kidney. It consists of a glomerulus - a tuft of capillaries composed of endothelial cells - and a glomerular capsule known as Bowman's capsule. [2]
Its chief function is to regulate the concentration of water and soluble substances like sodium by filtering the blood, reabsorbing what is needed and excreting the rest as urine. In the first part of the nephron, Bowman's capsule filters blood from the circulatory system into the tubules.
Diagram outlining movement of ions in nephron, with the collecting ducts on the right. The collecting duct system is the final component of the kidney to influence the body's electrolyte and fluid balance. In humans, the system accounts for 4–5% of the kidney's reabsorption of sodium and 5% of the kidney's reabsorption of water. At times of ...
The juxtaglomerular apparatus is part of the kidney nephron, next to the glomerulus. It is found between afferent arteriole and the thick ascending limb of the loop of Henle (distal straight tubule) of the same nephron. This location is critical to its function in regulating renal blood flow and glomerular filtration rate. [2] [3]
The nephron is the structural and functional unit of the kidney. Each adult human kidney contains around 1 million nephrons, while a mouse kidney contains only about 12,500 nephrons. The kidneys also carry out functions independent of the nephrons.
The proximal tubule is the segment of the nephron in kidneys which begins from the renal pole of the Bowman's capsule to the beginning of loop of Henle.At this location, the glomerular parietal epithelial cells (PECs) lining bowman’s capsule abruptly transition to proximal tubule epithelial cells (PTECs).
Within a single nephron, regenerative abilities differ between its parts. [199] In acute toxic and ischemic injuries, the tubules are able to regenerate and restore the function of the nephron. [196] In particular, the proximal part of the nephron, through which up to two-thirds of the primary urine is absorbed, [200] has the ability to ...