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The problem with this approach is that LDL-C values are commonly discordant with both direct measurements of LDL particles and actual rates of atherosclerosis progression. [ citation needed ] Direct LDL measurements are also available and better reveal individual issues but are less often promoted or done due to slightly higher costs and being ...
26119 100017 Ensembl ENSG00000157978 ENSMUSG00000037295 UniProt Q5SW96 Q8C142 RefSeq (mRNA) NM_015627 NM_145554 RefSeq (protein) NP_056442 NP_663529 Location (UCSC) Chr 1: 25.54 – 25.57 Mb Chr 4: 134.47 – 134.5 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Low-density lipoprotein receptor adapter protein 1 is a protein that in humans is encoded by the LDLRAP1 gene. The protein ...
In humans, excess cholesterol in the blood is captured by low-density lipoprotein (LDL) and removed by the liver via endocytosis of the LDL receptor. [4] Recent evidence indicates that the members of the LDL receptor gene family are active in the cell signalling pathways between specialized cells in many, if not all, multicellular organisms. [5 ...
The N-terminal domain of the LDL receptor, which is responsible for ligand binding, is composed of seven sequence repeats (~50% identical). Each repeat, referred to as a class A repeat or LDL-A, contains roughly 40 amino acids, including 6 cysteine residues that form disulfide bonds within the repeat. Additionally, each repeat has highly ...
where distance is the direct ... LDL cholesterol (Not valid when ... [116] 23 [117] 95, [117] 150 [116] nmol/L 25-hydroxycholecalciferol
A lipid profile or lipid panel is a panel of blood tests used to find abnormalities in blood lipid ( such as cholesterol and triglycerides) concentrations. [not verified in body] The results of this test can identify certain genetic diseases and can determine approximate risks for cardiovascular disease, certain forms of pancreatitis, and other diseases.
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Apolipoprotein B is the primary apolipoprotein of chylomicrons, VLDL, Lp(a), IDL, and LDL particles (LDL—commonly known as "bad cholesterol" when in reference to both heart disease and vascular disease in general), which is responsible for carrying fat molecules , including cholesterol, around the body to all cells within all tissues. While ...