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Solifenacin, sold as the brand name Vesicare [a] among others, is a medicine used to treat overactive bladder and neurogenic detrusor overactivity (NDO). [1] [2] It may help with incontinence, urinary frequency, and urinary urgency. [3] Benefits appear similar to other medications in the class. [4] It is taken by mouth. [1]
In interstitial cystitis, pentosan polysulfate is believed to work by providing a protective coating to the damaged bladder wall. Pentosan polysulfate is similar in structure to the natural glycosaminoglycan coating of the inner lining of the bladder, and may replace or repair the lining, reducing its permeability.
[5] [8] It works by blocking muscarinic receptors in the bladder thus decreasing bladder contractions. [6] Tolterodine was approved for medical use in 1998. [6] It is available as a generic medication. [5] In 2020, it was the 271st most commonly prescribed medication in the United States, with more than 1 million prescriptions. [9] [10]
If the retention is due to neurological damage, there is a disconnect between the brain to muscle communication, which can make it impossible to completely empty the bladder. [7] If the retention is due to muscle damage, it is likely that the muscles are not able to contract enough to completely empty the bladder. [7]
"The longer the bladder is full, the greater the likelihood of leakage of urine," Dr. Fromer says. In the short-term, you might feel embarrassed that you "peed your pants" and need a swift outfit ...
Trospium chloride is a muscarinic antagonist used to treat overactive bladder. [3] It has side effects typical of this class of drugs, namely dry mouth, stomach upset, and constipation; these side effects cause problems with people taking their medicine as directed.
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