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Deoxyribose, or more precisely 2-deoxyribose, is a monosaccharide with idealized formula H−(C=O)−(CH 2)−(CHOH) 3 −H. Its name indicates that it is a deoxy sugar, meaning that it is derived from the sugar ribose by loss of a hydroxy group. Discovered in 1929 by Phoebus Levene, [2] deoxyribose is most notable for its presence in DNA.
Each deoxyribonucleotide comprises three parts: a deoxyribose sugar (monosaccharide), a nitrogenous base, and one phosphoryl group. [1] The nitrogenous bases are either purines or pyrimidines , heterocycles whose structures support the specific base-pairing interactions that allow nucleic acids to carry information.
Specifically, DNase I, also known as FDA approved drug Pulmozyme (also known as dornase alfa) is used as a treatment to increase pulmonary function. Other respiratory illness such as asthma , [ 16 ] pleural empyema , [ 12 ] and chronic obstructive pulmonary disease have also been found to be positively affected by DNases properties.
For example, dATP stands for deoxyribose adenosine triphosphate. NTPs are the building blocks of RNA, and dNTPs are the building blocks of DNA. [12] The carbons of the sugar in a nucleoside triphosphate are numbered around the carbon ring starting from the original carbonyl of the sugar. Conventionally, the carbon numbers in a sugar are ...
Nucleosides are glycosylamines that can be thought of as nucleotides without a phosphate group.A nucleoside consists simply of a nucleobase (also termed a nitrogenous base) and a five-carbon sugar (ribose or 2'-deoxyribose) whereas a nucleotide is composed of a nucleobase, a five-carbon sugar, and one or more phosphate groups.
In its composition, deoxythymidine is a nucleoside composed of deoxyribose (a pentose sugar) joined to the pyrimidine base thymine. Deoxythymidine can be phosphorylated with one, two or three phosphoric acid groups, creating dTMP ( d eoxy t hymidine m ono p hosphate), dTDP , or dTTP (for the d i- and t ri- phosphates, respectively).
DERA is being used in chemical syntheses as a tool for green, enantioselective aldol reactions. Formation of the deoxyribose skeleton from small molecules can facilitate the synthesis of nucleoside reverse transcriptase inhibitors. [8] For example, DERA was used in a mixture of five enzymes in the biocatalytic synthesis of islatravir. [9]
Deoxycytidine can be phosphorylated at C5' of the deoxyribose by deoxycytidine kinase, converting it to deoxycytidine monophosphate (dCMP), a DNA precursor. [1] dCMP can be converted to dUMP and dTMP. It can also be used as a precursor for 5-aza-2′-deoxycytidine, a treatment for MDS patients.