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Pia mater (/ ˈ p aɪ. ə ˈ m eɪ t ər / or / ˈ p iː ə ˈ m ɑː t ər /), [1] often referred to as simply the pia, is the delicate innermost layer of the meninges, the membranes surrounding the brain and spinal cord. Pia mater is medieval Latin meaning "tender mother". [1] The other two meningeal membranes are the dura mater and the ...
A variant hemoglobin, called fetal hemoglobin (HbF, α 2 γ 2), is found in the developing fetus, and binds oxygen with greater affinity than adult hemoglobin. This means that the oxygen binding curve for fetal hemoglobin is left-shifted (i.e., a higher percentage of hemoglobin has oxygen bound to it at lower oxygen tension), in comparison to ...
It also increases oxygen availability to brain tissue and provides protection under hypoxic or ischemic conditions, potentially limiting brain damage. Neuroglobin were in the past found only in vertebrate neurons, but recently in 2013, were found in the neurons of unrelated protostomes , like photosynthetic acoel as well as radiata such as ...
The pia mater (Latin: tender mother) [9] is a very delicate membrane. It is the meningeal envelope that firmly adheres to the surfaces of the brain and spinal cord, following all of the brain's contours (gyri and sulci). It is a very thin membrane composed of fibrous tissue covered on its outer surface by a sheet of flat cells thought to be ...
The delicate arachnoid layer is not attached to the inside of the dura but against it, and surrounds the brain and spinal cord. It does not line the brain down into its sulci (folds), as does the pia mater, with the exception of the longitudinal fissure, which divides the left and right cerebral hemispheres.
Binding of oxygen to a heme prosthetic group. Heme (American English), or haem (Commonwealth English, both pronounced /hi:m/ HEEM), is a ring-shaped iron-containing molecular component of hemoglobin, which is necessary to bind oxygen in the bloodstream. It is composed of four pyrrole rings with 2 vinyl and 2 propionic acid side chains. [1]
The blood–brain barrier is formed by the brain capillary endothelium and excludes from the brain 100% of large-molecule neurotherapeutics and more than 98% of all small-molecule drugs. [28] Overcoming the difficulty of delivering therapeutic agents to specific regions of the brain presents a major challenge to treatment of most brain disorders.
A decrease in circulation in the brain vasculature due to stroke or injury can lead to a condition known as ischemia. In general, decrease in blood flow to the brain can be a result of thrombosis causing a partial or full blockage of blood vessels, hypotension in systemic circulation (and consequently the brain), or cardiac arrest. This ...