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The harmful effects of glutamate on the central nervous system were first observed in 1954 by T. Hayashi, a Japanese scientist who stated that direct application of glutamate caused seizure activity, [9] though this report went unnoticed for several years.
Glutamate is a very major constituent of a wide variety of proteins; consequently it is one of the most abundant amino acids in the human body. [1] Glutamate is formally classified as a non-essential amino acid, because it can be synthesized (in sufficient quantities for health) from α-ketoglutaric acid, which is produced as part of the citric acid cycle by a series of reactions whose ...
The glutamate hypothesis of schizophrenia models the subset of pathologic mechanisms of schizophrenia linked to glutamatergic signaling. The hypothesis was initially based on a set of clinical, neuropathological, and, later, genetic findings pointing at a hypofunction of glutamatergic signaling via NMDA receptors .
Excessive glutamate release is a known major cause of neuronal cell death. Glutamate causes neurotoxicity due to excitotoxicity and oxidative glutamate toxicity. Evidence from animal studies suggests that some people may be more genetically sensitive to the neurotoxic and brain damage associated with binge drinking regimes.
The reason for gradually increasing dosages, per Alan, is to lower the risk of side effects. “Too much too fast can cause unpleasant side effects, such as nausea and constipation,” Alan says.
Many adults who use ibuprofen and other anti-inflammatory drugs unwittingly take too much, increasing their risk of a slew of serious side effects.
Glutamate is the most prominent neurotransmitter in the body, and is the main excitatory neurotransmitter, being present in over 50% of nervous tissue. [2] [3] Glutamate was initially discovered to be a neurotransmitter in insect studies in the early 1960s.
The body needs cholesterol to build cells and make vitamins and certain hormones, but too much of it can cause fat to collect in arteries, increasing the risk of heart attack and stroke.