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An excipient is a substance formulated alongside the active ingredient of a medication.They may be used to enhance the active ingredient’s therapeutic properties; to facilitate drug absorption; to reduce viscosity; to enhance solubility; to improve long-term stabilization (preventing denaturation and aggregation during the expected shelf life); or to add bulk to solid formulations that have ...
Cellulose acetate phthalate (CAP), also known as cellacefate and cellulosi acetas phthalas, is a commonly used polymer phthalate in the formulation of pharmaceuticals, such as the enteric coating of tablets or capsules and for controlled release formulations.
Tablet coatings must be stable and strong enough to survive the handling of the tablet, must not make tablets stick together during the coating process, and must follow the fine contours of embossed characters or logos on tablets. Coatings are necessary for tablets that have an unpleasant taste, and a smoother finish makes large tablets easier ...
An enteric coating is a polymer barrier applied to oral medication that prevents its dissolution or disintegration in the gastric environment. [1] This helps by either protecting drugs from the acidity of the stomach, the stomach from the detrimental effects of the drug, or to release the drug after the stomach (usually in the upper tract of the intestine). [2]
A film coating is a thin polymer-based coat that is typically sprayed onto solid pharmaceutical dosage forms, such as tablets, capsules, pellets or granules. Film coating can impact both its appearance and its pharmacokinetics making it an essential process in making the final drug product.
Macrogol is used as an excipient in pharmaceutical products. [4] Lower-molecular-weight variants are used as solvents in oral liquids and soft capsules, whereas solid variants are used as ointment bases, tablet binders, film coatings, and lubricants. [21] For example, PEG-2000 is one of the excipients in the Moderna COVID-19 vaccine. [22] [23]
Glyceryl behenate is a fat used in cosmetics, foods, and oral pharmaceutical formulations.In cosmetics, it is mainly used as a viscosity-increasing agent in emulsions.. In pharmaceutical formulations, glyceryl behenate is mainly used as a tablet and capsule lubricant and as a lipidic coating excipient.
Improved tablet-to-tablet content uniformity due to a larger number of particles per unit weight; Controlled particle size distribution of dry granulation or mix to promote better flow of mixture in tablet machine; Improved flow properties of raw materials; Improved colour and/or active ingredient dispersion in tablet excipients