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Saline solution for irrigation. Normal saline (NSS, NS or N/S) is the commonly used phrase for a solution of 0.90% w/v of NaCl, 308 mOsm/L or 9.0 g per liter. Less commonly, this solution is referred to as physiological saline or isotonic saline (because it is approximately isotonic to blood serum, which makes it a physiologically normal solution).
Normal saline (NS) is the commonly used term for a solution of 0.9% w/v of NaCl, about 300 mOsm/L. [4] Less commonly, this solution is referred to as physiological saline or isotonic saline, neither of which is technically accurate.
This is due to urea entering the cell down its concentration gradient, followed by water. The osmolarity of normal saline, 9 grams NaCl dissolved in water to a total volume of one liter, is a close approximation to the osmolarity of NaCl in blood (about 290 mOsm/L). Thus, normal saline is almost isotonic to blood plasma.
Ringer's lactate solution has a lower rate of acidosis as compared with normal saline. [1] [4] Use is generally safe in pregnancy and breastfeeding. [2] Ringer's lactate solution is in the crystalloid family of medications. [5] It is isotonic, i.e. it has the same tonicity as blood. [2]
Phosphate-buffered saline (PBS) is a buffer solution (pH ~ 7.4) commonly used in biological research. It is a water-based salt solution containing disodium hydrogen phosphate, sodium chloride and, in some formulations, potassium chloride and potassium dihydrogen phosphate. The buffer helps to maintain a constant pH.
Physiologic saline solution, or 0.9% sodium chloride solution, is often used because it is isotonic, and therefore will not cause potentially dangerous fluid shifts. Also, if it is anticipated that blood will be given, normal saline is used because it is the only fluid compatible with blood administration. [citation needed]
To prepare an isotonic saline solution for nasal rinsing, approx. 0.25 liter lukewarm, sterilized drinking water and 2.5 ml of table salt (about half a level teaspoon) is required. Nasal irrigation device commonly available at pharmacies
Isotonic solutions have the same salt concentration as the human body, whereas hypertonic solutions have a higher salt content and hypotonic solutions have a lower salt content. Isotonic saline nasal sprays are commonly used in infants and children to wash out the thick mucus from the nose in case of allergic rhinitis.
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