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Tiotropium is a muscarinic receptor antagonist, often referred to as an antimuscarinic or anticholinergic agent. Although it does not display selectivity for specific muscarinic receptors, when topically applied it acts mainly on M 3 muscarinic receptors [ 29 ] located on smooth muscle cells and submucosal glands.
EA-3167 is a potent and long-lasting anticholinergic deliriant drug, related to the chemical warfare agent 3-quinuclidinyl benzilate (QNB) and to the bronchodilator drug tiotropium bromide. It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program , in an attempt to develop non ...
A bromide ion is the negatively charged form (Br −) of the element bromine, a member of the halogens group on the periodic table.Most bromides are colorless. Bromides have many practical roles, being found in anticonvulsants, flame-retardant materials, and cell stains. [3]
Both M 2 and M 3 muscarinic receptors are expressed in the smooth muscles of the airway, with the majority of the receptors being the M 2 type. Activation of the M 2 receptors, which are coupled to G i, inhibits the β-adrenergic mediated relaxation of the airway smooth muscle.
Long-acting muscarinic antagonists, including tiotropium, aclidinium and umeclidinium, are indicated for severe asthma in maintenance treatment. [ 2 ] Muscarinic antagonists can reduce cholinergic bronchomotor tone, resulting in airway muscle relexation and bronchodilation.
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Ipratropium bromide, sold under the brand name Atrovent among others, is a type of anticholinergic medication which is applied by different routes: inhaler, nebulizer, or nasal spray, for different reasons. [1] [2] The inhalant opens up the medium and large airways in the lungs.
Introduction Tiotropium bromide is an inhaled, once-daily, long-acting anticholinergic (long-acting muscarinic receptor antagonist [LAMA]) bronchodilator available as an inhalation solution via the Respimat® Soft Mist™ Inhaler (SMI) and as a dry powder for inhalation via the HandiHaler® device.1,2 Tiotropium is marketed under the brand name ...
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109 S High St #100, Columbus, OH · Directions · (614) 224-4261
"The lowest prices on generic prescriptions." - The New York Times