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Immunoglobulin E (IgE) is a type of antibody (or immunoglobulin (Ig) "isoform") that has been found only in mammals. IgE is synthesised by plasma cells. Monomers of IgE consist of two heavy chains (ε chain) and two light chains, with the ε chain containing four Ig-like constant domains (Cε1–Cε4). [1]
The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotype involved in allergy disorders and parasite immunity. FcεRI is a tetrameric receptor complex that binds Fc portion of the ε heavy chain of IgE. [1]
The final rearrangement of the light chain gene generates immature B cell and membrane-bound IgM (mIgM). [5] The process explained here occurs during development of naïve B cells, prior to exposure to exogenous antigens. The mature B cell formed as a result of these processing changes leaves the bone marrow and may then be stimulated by an ...
Mechanism of class-switch recombination that allows isotype switching in activated B cells. Immunoglobulin class switching, also known as isotype switching, isotypic commutation or class-switch recombination (CSR), is a biological mechanism that changes a B cell's production of immunoglobulin from one type to another, such as from the isotype IgM to the isotype IgG. [1]
Production of a viable heavy chain is a key step in B cell maturation. If the heavy chain is able to bind to a surrogate light chain and move to the plasma membrane, then the developing B cell can begin producing its light chain. [2] The heavy chain does not always have to bind to a light chain. Pre-B lymphocytes can synthesize heavy chain in ...
n/a Ensembl ENSG00000211891 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 14: 105.6 – 105.6 Mb n/a PubMed search n/a Wikidata View/Edit Human Ig epsilon chain C region is a protein that in humans is encoded by the IGHE gene. Function IGHE (Immunoglobulin Heavy constant Epsilon), (located on chromosome 14 for humans) has been predicted to enable ...
The J chain gene is transcriptionally regulated through canonical Pax5 repression. [24] As Pax5 is a common transcriptional regulator, the J chain is still expressed in plasma cells that secrete monomeric antibodies. In such cells it is believed to provide no function and is quickly degraded. [19]
[17] sIgA has also been shown to potentiate the immune response in intestinal tissue by uptake of antigen together with the bound antibody by dendritic cells. [18] IgE antibodies are present at lowest concentrations in peripheral blood but constitute the main antibody class in allergic responses through the engagement of mast cells, eosinophils ...