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AP-1 was first discovered as a TPA-activated transcription factor that bound to a cis-regulatory element of the human metallothionein IIa promoter and SV40. [3] The AP-1 binding site was identified as the 12-O-Tetradecanoylphorbol-13-acetate response element (TRE) with the consensus sequence 5’-TGA G/C TCA-3’. [4]
Housekeeping genes account for majority of the active genes in the genome, and their expression is obviously vital to survival. The housekeeping gene expression levels are fine-tuned to meet the metabolic requirements in various tissues.
Genomics is an interdisciplinary field of molecular biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA , including all of its genes as well as its hierarchical, three-dimensional structural configuration.
22341 Ensembl ENSG00000150630 ENSMUSG00000031520 UniProt P49767 P97953 RefSeq (mRNA) NM_005429 NM_009506 RefSeq (protein) NP_005420 NP_033532 Location (UCSC) Chr 4: 176.68 – 176.79 Mb Chr 8: 54.53 – 54.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Vascular endothelial growth factor C (VEGF-C) is a protein that is a member of the platelet-derived growth factor / vascular ...
Physiomics arose from the imbalance between the amount of data being generated by genome projects and the technological ability to analyze the data on a large scale. [3] As technologies such as high-throughput sequencing were being used to generate large amounts of genomic data, effective methods needed to be designed to experimentally interpret and computationally organize this data. [5]
Associated with each stage is the corresponding systems biology tool, from genomics to metabolomics. Metabolomics is the scientific study of chemical processes involving metabolites , the small molecule substrates, intermediates, and products of cell metabolism .
The TCF7L2 gene, encoding the TCF7L2 protein, is located on chromosome 10q25.2-q25.3. The gene contains 19 exons. [7] [8] Of the 19 exons, 5 are alternative. [8]The TCF7L2 protein contains 619 amino acids and its molecular mass is 67919 Da. [26]
Transcription factor COE1 is a protein that in humans is encoded by the EBF1 gene.EBF1 stands for Early B-Cell Factor 1. [5] [6] [7]EBF1 controls the expression of key proteins required for B cell differentiation, signal transduction and function.