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  2. Loop diuretic - Wikipedia

    en.wikipedia.org/wiki/Loop_diuretic

    At the same time, loop diuretics inhibit the tubuloglomerular feedback mechanism so that increase in salts at the lumen near macula densa does not trigger a response that reduces the GFR. [6] Loop diuretics also inhibit magnesium and calcium reabsorption in the thick ascending limb. Absorption of magnesium and calcium are dependent upon the ...

  3. Diuretic - Wikipedia

    en.wikipedia.org/wiki/Diuretic

    The antihypertensive actions of some diuretics (thiazides and loop diuretics in particular) are independent of their diuretic effect. [ 1 ] [ 2 ] That is, the reduction in blood pressure is not due to decreased blood volume resulting from increased urine production , but occurs through other mechanisms and at lower doses than that required to ...

  4. Thiazide - Wikipedia

    en.wikipedia.org/wiki/Thiazide

    Illustration of the mechanism of action of thiazide diuretics in the distal convoluted tubule of nephrons. Thiazide diuretics control hypertension in part by inhibiting reabsorption of sodium (Na +) and chloride (Cl −) ions from the distal convoluted tubules in the kidneys by blocking the thiazide-sensitive Na +-Cl − symporter. [31]

  5. Potassium-sparing diuretic - Wikipedia

    en.wikipedia.org/wiki/Potassium-sparing_diuretic

    Potassium-sparing diuretics or antikaliuretics [1] refer to drugs that cause diuresis without causing potassium loss in the urine. [2] They are typically used as an adjunct in management of hypertension , cirrhosis , and congestive heart failure . [ 3 ]

  6. Furosemide - Wikipedia

    en.wikipedia.org/wiki/Furosemide

    The action on the distal tubules is independent of any inhibitory effect on carbonic anhydrase or aldosterone; it also abolishes the corticomedullary osmotic gradient and blocks negative, as well as positive, free water clearance. Because of the large NaCl absorptive capacity of the loop of Henle, diuresis is not limited by the development of ...

  7. Renal physiology - Wikipedia

    en.wikipedia.org/wiki/Renal_physiology

    Diagram showing the basic physiologic mechanisms of the kidney. The kidney's ability to perform many of its functions depends on the three fundamental functions of filtration, reabsorption, and secretion, whose sum is called renal clearance or renal excretion. That is: Urinary excretion rate = Filtration rate – Reabsorption rate + Secretion ...

  8. Osmotic diuretic - Wikipedia

    en.wikipedia.org/wiki/Osmotic_diuretic

    An osmotic diuretic is a type of diuretic that inhibits reabsorption of water and sodium (Na). They are pharmacologically inert substances that are given intravenously. They increase the osmolarity of blood and renal filtrate. [1] This fluid eventually becomes urine. Two examples are mannitol [2] and isosorbide.

  9. Chlorothiazide - Wikipedia

    en.wikipedia.org/wiki/Chlorothiazide

    Chlorothiazide, sold under the brand name Diuril among others, is an organic compound used as a diuretic and as an antihypertensive. [1] [2] It is used both within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. Most often taken in pill form, it is usually taken orally once or twice a day.

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