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Pancreatic enzymes have been used as medications since at least the 1800s. [7] They are on the World Health Organization's List of Essential Medicines. [8] In 2022, it was the 253rd most commonly prescribed medication in the United States, with more than 1 million prescriptions. [9] [10]
Lipase inhibitors can be found naturally in plants and can also be produced as pharmaceutical drugs.Some lipase inhibitors have been identified in Panax ginseng. [5] [6] Some active compounds with chalcone scaffold found in Glycyrrhiza glabra, Cassia mimosoides, Glycyrrhiza uralensis, Boesenbergia rotunda, apples and Morus alba also had strong effect against lipase.
Lipase inhibitors belong to a drug class that is used as an antiobesity agent. Their mode of action is to inhibit gastric and pancreatic lipases, enzymes that play an important role in the digestion of dietary fat. [2] Lipase inhibitors are classified in the ATC-classification system as A08AB (peripherally acting antiobesity products). [3]
A key difference between prescription and over-the-counter digestive enzymes is that the US Food and Drug Administration regulates the former as drugs, “so they undergo a rigorous approval ...
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There's also metabolic enzymes, which belong to the transferases category and help convert food into energy; or repair enzymes, that help fix damaged or mutated DNA.
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