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Phineas P. Gage (1823–1860) was an American railroad construction foreman remembered for his improbable: 19 survival of an accident in which a large iron rod was driven completely through his head, destroying much of his brain's left frontal lobe, and for that injury's reported effects on his personality and behavior over the remaining 12 years of his life—effects sufficiently ...
Damage to the frontal lobe can cause increased irritability, which may include a change in mood and an inability to regulate behavior. [1] Particularly, an injury of the frontal lobe could lead to deficits in executive function , such as anticipation, goal selection, planning, initiation, sequencing, monitoring (detecting errors), and self ...
Frontal lobe disorder, also frontal lobe syndrome, is an impairment of the frontal lobe of the brain due to disease or frontal lobe injury. [5] The frontal lobe plays a key role in executive functions such as motivation, planning, social behaviour, and speech production. Frontal lobe syndrome can be caused by a range of conditions including ...
This personality change is characteristic of damage to the frontal lobe, and was exemplified in the case of Phineas Gage. The frontal lobe is the same part of the brain that is responsible for executive functions such as planning for the future, judgment, decision-making skills, attention span, and inhibition. These functions can decrease ...
Early cases of Witzelsucht observed damage to the mesial-orbital region of the frontal lobe. [6] In general, damage to this area results in puerility, disinhibition, and an inappropriate jocular affect. Subjects with damage to this part of the brain show a preference for gallows humor [citation needed]. The frontal lobes are also involved in ...
Perseveration is a common feature of frontal lobe syndrome, as well as neurodegenerative diseases such as progressive supranuclear palsy, corticobasal syndrome and chronic acetogenin poisoning. [8] Perseveration may also refer to the obsessive and highly selective interests of individuals on the autism spectrum.
Perhaps the first reported case of personality change after brain injury is that of Phineas Gage, who survived an accident in which a large iron rod was driven through his head, destroying one or both of his frontal lobes; numerous cases of personality change after brain injury have been reported since. [31] [33] [34] [43] [44] [48] [185] [186]
A famous example is Phineas Gage, whose personality appears to have changed (though not as dramatically as usually described) after a perforating injury to his frontal lobe(s). People with subarachnoid hemorrhage, a blown pupil, respiratory distress, hypotension, or cerebral vasospasm are more likely to have worse outcomes. [5]