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In 1927, Sakel, who had recently qualified as a medical doctor in Vienna and was working in a psychiatric clinic in Berlin, began to use low (sub-coma) doses of insulin to treat drug addicts and psychopaths, and when one of the patients experienced improved mental clarity after having slipped into an accidental coma, Sakel reasoned the treatment might work for mentally ill patients. [3]
An insulin overdose was nearly impossible to peg as a cause of death. In multiple cases, it was William Dale Archerd's choice of poison, police said. His wives kept dying mysteriously.
Glucagon is a hormone that rapidly counters the metabolic effects of insulin in the liver, causing glycogenolysis and release of glucose into the blood. It can raise the glucose by 30–100 mg/dL within minutes in any form of hypoglycemia caused by insulin excess (including all types of diabetic hypoglycemia).
[3] [2] [24] Some people may use insulin to induce weight loss, whereas for others this may be due to malingering or factitious disorder, which is a psychiatric disorder. [24] Demographics affected by factitious hypoglycemia include women aged 30–40, particularly those with diabetes, relatives with diabetes, healthcare workers, or those with ...
Insulin shock A severe condition that occurs when the level of blood glucose (sugar) drops too far and quickly. The signs are shaking, sweating, dizziness, double vision, convulsions, and collapse. Insulin shock may occur when an insulin reaction is not treated quickly enough. In severe cases, brain damage, nerve damage, or even death is possible.
Insulin shock therapy was discontinued due to critical concerns over its safety and effectiveness. This method, which induced comas in patients through insulin injections, resulted in severe adverse effects, including hypoglycemic episodes, seizures , obesity , and in some cases, irreversible brain damage that was mistakenly regarded as ...
Bret Michaels and his band Poison were no strangers to sex, drugs and rock ‘n’ roll in the 1980s, but the hair metal lifestyle was hard on Michaels for a different reason. Michaels, now 61 ...
DKA results from significantly low insulin levels due to various factors including undiagnosed diabetes (people who did not know they have diabetes), missed or delayed doses, insufficient insulin administration, or undergoing physiological stress (e.g. infection, surgery, Stroke, or trauma). [9] [10]