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β-Hydroxy β-methylbutyric acid [note 1] (HMB), otherwise known as its conjugate base, β-hydroxy β-methylbutyrate, is a naturally produced substance in humans that is used as a dietary supplement and as an ingredient in certain medical foods that are intended to promote wound healing and provide nutritional support for people with muscle wasting due to cancer or HIV/AIDS.
Butyrate fermentation is a process that produces butyric acid via anaerobic bacteria. This process occurs commonly in clostridia which can be isolated from many anaerobic environments such as mud, fermented foods, and intestinal tracts or feces. [1]
A number of specific diets and diet-based regimes have been claimed to be useful against cancer, including the Breuss diet, Gerson therapy, the Budwig protocol and the macrobiotic diet. None of these diets has been found to be effective, and some of them have been found to be harmful. [16]
Bacteroides thetaiotaomicron is a common bacterium in the human gut microbiome that has evolved alongside humans to support digestion and general health. Over time, this bacterium developed the ability to break down complex carbohydrates into simple sugars, which helps the host species get more energy from the food it eats.
Dietary fibre from fruits, vegetables and grain foods. Insoluble dietary fibre is not absorbed in the human digestive tract but is important in maintaining the bulk of a bowel movement to avoid constipation. [5] Soluble fibre can be metabolized by bacteria residing in the large intestine.
Acetate, propionate and butyrate are the three most common SCFAs. [3] Butyrate is particularly important for colon health because it is the primary energy source for colonocytes (the epithelial cells of the colon). [1] [2] The liver can use acetate for energy. [5]
Nutrition and diet are closely associated with the leading causes of death, including cardiovascular disease and cancer. Obesity and high sodium intake can contribute to ischemic heart disease, while consumption of fruits and vegetables can decrease the risk of developing cancer.
Sodium phenylbutyrate, sold under the brand name Buphenyl among others, is a salt of an aromatic fatty acid, 4-phenylbutyrate (4-PBA) or 4-phenylbutyric acid. [7] The compound is used to treat urea cycle disorders, because its metabolites offer an alternative pathway to the urea cycle to allow excretion of excess nitrogen.