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The term seizure threshold is used to describe the balance between excitatory (glutaminergic) and inhibitory (GABA-ergic) forces in the brain which affect how susceptible a person is to seizures. Those diagnosed with epilepsy or certain other neurological conditions are more vulnerable to seizures if the threshold is reduced, and should be ...
This progressively lowers the threshold needed to cause alcohol-related brain damage and cognitive impairments, leading to altered neurological function. The changes in activity of excitatory and inhibitory neurotransmitter systems is similar to that which occurs in individuals suffering from limbic or temporal lobe epilepsy .
Methadone maintenance has been shown to reduce the transmission of bloodborne viruses associated with opioid injection, such as hepatitis B and C, and/or HIV. [10] The principal goals of methadone maintenance are to relieve opioid cravings, suppress the abstinence syndrome, and block the euphoric effects associated with opioids.
[67] [78] [79] [80] Some antipsychotic agents may be riskier than others during withdrawal, especially clozapine, olanzapine or low potency phenothiazines (e.g., chlorpromazine), as they lower the seizure threshold and can worsen withdrawal effects; if used, extreme caution is required. [81]
Peak incidence of seizures occurs at 24-36 hours [5] and peak incidence of delirium tremens is at 48-72 hours. [6] Alcohol withdrawal may occur in those who are alcohol dependent. [1] This may occur following a planned or unplanned decrease in alcohol intake. [1] The underlying mechanism involves a decreased responsiveness of GABA receptors in ...
Similar to fentanyl, a highly potent synthetic opioid, methadone stimulates opioid receptors, making it possible to overdose on the medication, said Matthew Rogalski, an addiction medicine ...
Lane County Commissioners approved the new Oregon Recovery and Treatment Centers methadone clinic at 98 East 11th Ave. The ORTC must now get approval from the Oregon Health Authority, federal Drug ...
Drug withdrawal, drug withdrawal syndrome, or substance withdrawal syndrome [1] is the group of symptoms that occur upon the abrupt discontinuation or decrease in the intake of pharmaceutical or recreational drugs. In order for the symptoms of withdrawal to occur, one must have first developed a form of drug dependence.
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