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This is a list of adverse effects of the antidepressant trazodone, sorted by frequency of occurrence. [1] [2] [3] Very common.
It has relatively low affinity for α 1-adrenergic receptors unlike trazodone, but does have high affinity for α 2-adrenergic receptors and weak affinity for the H 1 receptor. [12] In addition to direct interactions with serotonin receptors, mCPP is a serotonin releasing agent similarly to agents like fenfluramine and MDMA.
[4] [5] Antipsychotics like quetiapine and olanzapine and antidepressants like trazodone and mirtazapine are all potent serotonin 5-HT 2A receptor antagonists. [ 6 ] [ 28 ] [ 29 ] Conversely, benzodiazepines and alcohol act as positive allosteric modulators of the GABA A receptor and have anxiolytic and sedative effects. [ 30 ]
An atypical antidepressant is any antidepressant medication that acts in a manner that is different from that of most other antidepressants. Atypical antidepressants include agomelatine, bupropion, iprindole, mianserin, mirtazapine, nefazodone, opipramol, tianeptine, and trazodone.
Niaprazine (Nopron) – a drug related to this group but does not inhibit the reuptake of serotonin or the other monoamines. Medifoxamine (Clédial, Gerdaxyl) – could perhaps technically be said to belong to this group, as it is a serotonin–dopamine reuptake inhibitor and 5-HT 2A and 5-HT 2C receptor antagonist, but not grouped as such. [1]
SSRIs mediate their action largely with high occupancy in a total of all serotonin transporters within the brain and through this slow downstream changes of large brain regions at therapeutic concentrations, whereas MDMA leads to an excess serotonin release in a short run. This could explain the absence of a "high" by antidepressants and in ...
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[4] [5] [2] Symptoms in mild cases include high blood pressure and a fast heart rate; usually without a fever. [2] Symptoms in moderate cases include high body temperature, agitation, increased reflexes, tremor, sweating, dilated pupils, and diarrhea. [1] [2] In severe cases, body temperature can increase to greater than 41.1 °C (106.0 °F). [2]