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Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK, the West Indies ...
It works by decreasing the amount of thyroid hormone produced by the thyroid gland and blocking the conversion of thyroxine (T4) to triiodothyronine (T3). [3] Propylthiouracil came into medical use in the 1940s. [5] It is on the World Health Organization's List of Essential Medicines. [6]
Treatment consists of a daily dose of thyroid hormone by mouth. Because the treatment is simple, effective, and inexpensive, most of the developed world utilizes newborn screening with blood thyroid stimulating hormone (TSH) levels to detect congenital hypothyroidism. Most children with congenital hypothyroidism correctly treated with thyroxine ...
Desiccated thyroid extract is prepared from pig thyroid glands. The glands are dried (desiccated), ground to powder, combined with binder chemicals, and pressed into pills. This was a new use for parts that were previously unwanted slaughterhouse offal , and Armour and Company , the dominant American meatpacker in the 20th century, supplied the ...
Thyroid hormone replacement with levothyroxine treats hypothyroidism. [3] Medical professionals adjust the dose according to symptoms and normalization of the thyroxine and TSH levels. [3] Thyroid medication is safe in pregnancy. [3] Although an adequate amount of dietary iodine is important, too much may worsen specific forms of hypothyroidism ...
The thyroid is found in the neck, and is responsible for producing hormones that in turn play a role in metabolism, growth and development in children, temperature regulation and in the ...
The recommended standard (daily) dose of KI for all school-age children is the same (65 mg). However, adolescents approaching adult size (i.e., >70 kg [154 lbs]) should receive the full adult dose (130 mg) for maximal block of thyroid radioiodine uptake. Neonates ideally should receive the lowest dose (16 mg) of KI." [31]
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